Children Get Smarter From Taking Fish Oil

October 24, 2005

The omega-3 fatty acid DHA in fish oil is an important building block for the brain. DHA deficiency in the first years of life may impact the normal development of the child’s brain.

Are children getting smarter from eating fish? Recent studies suggest that fatty acids in fish oil can help certain children with ADHD or dyslexia. But what about infants?

From the last third of fetal life to the end of the second year of life, children’s brains grow so strongly that one speaks of a brain growth spurt. During this period, a lack of a number of vital nutrients, such as fish oil, will affect brain function. The American Journal of Clinical Nutrition recently published a comprehensive review of what is known about fish and young children’s brains.

As a starting point, it is known that the polyunsaturated n-3 fatty acid DHA (docosahexaenoic acid) is highly concentrated in the cell walls of nerve cells. DHA is one of the two important n-3 fatty acids in fish oil. The other is EPA (eicosa-pentaenoic acid). EPA can be converted to DHA, and to a certain extent they can both be formed from the n-3 fatty acid alpha-linolenic acid in e.g. linseed oil.

But does it form enough in a child who is not breastfed or gets oily fish? The question is relevant. It is known that breast-fed babies have up to 40% more DHA in the brain’s gray matter than bottle-fed babies. In addition, it is known that young animals and probably also infants, even if they are neither near-sighted nor far-sighted, will see a little less sharply if they lack n-3 fatty acids. The significance of this is debated.

The importance of DHA has been investigated e.g. by comparing bottle-fed babies with breast-fed babies who got DHA from breast milk. Bottle babies have also been compared with other bottle babies who have received n-3-enriched formula. The children have been tested for intellectual and motor development, attention, etc.

Greater attention
In these kinds of experiments, it has been shown that breast-fed babies fare slightly better on average than bottle-fed babies. But is the difference due to DHA? Nursing mothers may function slightly better than non-nursing mothers, and may have better social relationships, etc. When you correct for this, the differences diminish. Furthermore, there are many other differences between milk substitute and mother’s milk other than the DHA content.

It becomes somewhat clearer when you compare bottle babies, where only half receive extra n-3 supplements. Here the results have been mixed, but on one point a difference has been seen quite consistently: Infants who receive n-3 supplements have a greater capacity for visual attention, i.e. to follow the things they see. This important result has also been obtained in experiments with monkeys.

In animal experiments with rodents, the clearest differences have been found. This is due, among other things, to the fact that these experiments can be set up, so that the difference in brain DHA becomes particularly large. Animals that are starved of n-3 fat become less agile, find it harder to find their way around a maze, etc. Even if there are only minor differences in brain DHA, the animals that do not get fish oils are weakened. Roughly speaking, this is what is known.

So what can be concluded? The authors do not claim that children should demonstrably have n-3 supplementation during the brain spurt. But they claim, after sifting through 258 scientific papers, that the need cannot be ruled out.

– Small differences in brain DHA, which most likely occur between bottle-fed babies with and without n-3 supplementation, may have effects that are currently difficult to detect but could be important, it says. Or to put it more simply: Remember to give babies and toddlers fatty fish or fish oil! They seem to be getting wiser from it.

By: Vitality Council

Reference:
Mc Cann J C, Ames, Bruce N. Is docosahexaenoic acid, an n-3 long chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioural tests in humans and animals. Am J Clin Nutr 2005;82:281-95

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Antioxidants Relieve the Adverse Effects of Chemotherapy

November 15, 2004

Children suffering from leukaemia tend to be more ill and be hospitalized longer if they are not given antioxidants.

The primary effect of chemotherapy is not through free radical activity but it does strain the organism with free radicals. Free radicals are combatted by antioxidants like vitamin C and -E. This piece of information is important, because not taking enough antioxidants while going through chemoterapy will result in more adverse effects and the treatment results can be delayed.

American doctors from several universities have published these results after having studied 103 children receiving chemotherapy for leukaemia. An evaluation of the children’s diet showed that they usually only got 1/3 – 2/3 of the recommended or normal amounts of various antioxidants. The reason for this is probably the treatment causing general malaise and reduced appetite.

The children who got the most vitamin C were hospitalized for a significantly shorter period and the children who got the most vitamin E suffered fewer infections and fewer adverse effects of the chemotherapy. The doctors conclude that a low intake of antioxidants results in more negative effects of the treatment.

The results can be related to a study of 49 American women who received chemotherapy for breast cancer and were asked about their use of dietary supplements. Multivitamins and vitamin E were the preferred supplements among the 35 women who did use supplements.

The women who took these vitamins maintained a better immune defence during the treatment – i.e. the number of white blood cells in their blood was less reduced during treatment compared to the women who did not use vitamin supplements. On the other hand, the number of white blood cells was more reduced in women taking relatively large amounts of the vitamin B9, folic acid.

It is very common for cancer patients to use dietary supplements. More than every other cancer patient at a hospital clinic in London used supplements, but less than half of them had told their GP about it.

By: Vitality Council

Source:
Kennedy DD, Tucker KL, Ladas ED, et al. Low antioxidant vitamin intakes are associated with increases in adverse effects of chemotherapy in children with acute lymphoblastic leukemia. Am J Clin Nutr (United States), Jun 2004, 79(6) p1029-36.

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Pregnant Women Addicted to Alcohol Should Take Antioxidants

August 30, 2004

Every year, about a hundred children, who are severely damaged by their mother’s alcohol abuse, are born in Denmark. These children, born with the so called foetal alcohol syndrome (FAS), suffer from mental retardation, decreased growth, heart failure, striking malformations of their face, arms, and legs, and also suffer cardiac malformations.

Researchers at a centre for alcohol studies at the University of North Carolina now believe that some of these malformations can be avoided if pregnant women with an incontrollable alcohol consumption receive an antioxidant supplement, e.g. vitamin E. The viewpoint is that if the mothers are not capable of holding back – and this, of course, is the exact problem of alcoholics, it would be better to try to reduce the damages rather than making impossible demands.

The information is based on studies with foetal mice who were exposed to alcohol. It turned out that the nervous cells of the foetuses which are easily damaged by alcohol is partly protected by the antioxidant SOD. This indicates that the damages are caused by the formation of so-called free radicals and the researchers at the centre have already established that vitamin E, which is also an antioxidant, reduces these damages.

In the actual study, the mice were born with significantly less malformed limbs when they were protected by SOD. Based on this, the conductor of the study, professor Kathleen K. Sulik claimed that it would be “wonderful” if pregnant women with alcohol problems could be persuaded into taking vitamin supplements.

The number of babies who are born with more discrete alcohol damages is not known. An estimated consumption of only one drink a day can increase the risk of abortion and result in growth retardation of several hundred grams while the baby is still in its mother’s womb.

By: Vitality Council

References:
1. Protection from ethanol-induced limb malformations by the superoxide dismutase/catalase mimetic, EUK-134. Chen SY, Dehart DB, Sulik KK. FASEB J. 2004.
2. Graviditet og alkohol [Pregnancy and alcohol]. Sundhedsstyrelsen 1999.

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