Vitamin B12, Research references

January 1999

1. Allen, LH, Casterline J. Vitamin Bl2 deficiency in elderly individuals. diagnosis and requirements. Am J Clin Nutr 60: 12-14, 1994.
2. Baker H et al. Plasma vitamin B12 titres as indicators of disease severity and mortality of patients with alcoholic hepatitis. Alcohol Alcoholism 22; (1):15, 1987.
3. Brinton LA, Gridley G, Hrubec A et al. Cancer risk following pernicious anemia. Br J Cancer 59: 810-813, 1989.
4. Campbell RE, Pruitt FW. Vitamin B12 in the treatment of viral hepatitis. Am J Med Sci 224:252, 1952.
5. Campbell RE, Pruitt FW. The effect of vitamin B12 and folic acid in the treatment of viral hepatitis. Am J Med Sci 229:8-15, 1955.
6. Carethers M. Diagnosing vitamin Bl2 deficiency, a common geriatric disorder. Geriatrics 43: 89-112, 1988.
7. Chu RC, Hall CA. The total serum homocysteine as an indicator of vitamin Bl2 and folate status. Am J Clin Pathol 90: 446-449, 1988.
8. Dalery K et al. Homocysteine and coronary artery disease in French Canadian subjects: Relation with vitamins B12, B6, pyridoxal phosphate and folate. Am J Cardiol 75:1107-11, 1995.
9. Davidson S. The Use of Vitamin B12 in the Treatment of Diabetic Neuropathy. J Flor Med Assoc 15: 717-20, 1954.
10. Doscherholmen A, Swaim WR. Impaired assimilation of egg 57 Co vitamin Bl2 in patients with hypochlorhydria and achlorhydria and after gastric resection. Gastroenterol 1973; 64: 913-919.
11. Ellis FR, Nasser S. A pilot study of vitamin B12 in the treatment of Tiredness. Br J Nutr 30: 277-83, 1973.
12. Gaby SK, Bendich A. Vitamin intake and health: A scientific review. New York: Marcel Dekker. p 193-197, 1991.
13. Gaby AR. The story of vitamin B12: Is vitamin B12 a panacea or placebo? Nutrition & Healing 2; 7, July, 1995.
14. Goodman KI, Salt WB 2nd. Vitamin B12 deficiency. Important new concepts in recognition. Postgrad Med 88; 3: 147-50, 153-8, 1990.
15. Gupta AK, Mital H.S. Cyanocobalamin (vitamin B12) in the management of Herpes Zoster. Indian Pract 20; (7):457-9, 1967.
16. Harriman GR et al. Vitamin B12 malabsorption in patients with acquired immunodeficiency syndrome. Arch Intern Med 149; (9):2039-41, 1989.
17. Heyblon R. Vitamin B12 in herpes zoster. Abstract. JAMA 146:1338, 1951.
18. Herbert, V. Vitamin B-l2. In: Present knowledge in nutrition. 7th edn. Washington DC: International Life Sciences Press. 1996: p 191-205.
19. Heimburger DC, Alexander CB, Birch R, Bailey WC, Krumdieck CL. Improvement in bronchial squamous metaplasia in smokers treated with folate and vitamin Bl2. J Am Mcd Assoc 259: 1525-1530, 1988.
20. Herbert V. B12 deficiency and AIDS. Letter. JAMA 260; (19):2837, 1988.
21. Herzlich BC et al. Synergy of inhibition of DNA synthesis in human bone marrow by azidothymidine plus deficiency of folate and/or vitamin B12? Am J Hematology 33:177-83, 1990.
22. Hjelt K, Krasilnikoff PA. The impact of gluten on haematolgical status, dietary intakes of haemopoietic nutrients and vitamin B12 and folic acid absorption in children with coeliac disease. Acta Paediatr Scand 79; (10):911-19, 1990.
23. Inada M, Toyoshima M, Kameyama M. Brain content of cobalamin and its binders in elderly subjects. J Nutr Sci Vitaminol 28: 351-357, 1982.
24. Kokkonen J, Similä S. Gastric function and absorption of vitamin B12 in children with celiac disease. Eur J Pediatr 132; (2):71-5, 1979.
25. Lederle FA. Oral cobalamin for pernicious anemia. Medicine’s best kept secret? JAMA. 265: 94-95, 1991.
26. Nilsson-Ehle H, Landahl S, Lindstealt G et al. Low serum cobalamin levels in population study of 70- and 75-year-old subjects. Dig Dis Sci 34: 716-723, 1989.
27. Olszewski AJ, Szostak WB, McCully KS. Plasma glucosamine and galactosamine in ischemic heart disease. Atherosclerosis 75:1-6, 1989.
28. Omaye ST. Nutritional and toxicological aspects of food safety. New York: Plenum Press. p 169-203, 1984.
29. Richardson LR, Brock R. Studies of reproduction in rats using large doses of vitamin Bl2 and highly purified soybean proteins. J Nutr 1956; 58: 135-145.
30. Robertson KR et al. Vitamin B12 Deficiency and Nervous System Disease in HIV Infection, Arch Neurol 50:807-11, 1993.
31. Rule SAJ et al. Serum vitamin B12 and Transcobalamin levels in early HIV Disease. Am J Hematol 47:167-71, 1994.
32. Shemesh Z et al. Vitamin B12 deficiency in patients with chronic tinnitus and noise-induced hearing loss. Am J Otolaryngol 14; (2):94-9, 1993.
33. Shils ME, Young VR. Modem Nutrition in Health and Disease. 7th edn. Lea and Febiger. p 401-404, 1988.
34. Tang AM, Graham NM, Chandra RK, Saah AJ. Low Serum Vitamin B-12 concentrations are associated with Faster Human Immunodeficiency Virus type 1 (HIV-1) disease progression. J Nutr 127:345-51, 1997.
35. Ubbink JB, Vermaak WJH, van der Merwe A, Becker PJ. Vitamin B-12, vitamin B-6, and folate nutritional status in men with hyperhomocysteinemia. Am J Clin Nutr 57: 47-53, 1993.
36. Uchizyama M et al. Effects of vitamin B12 on human circadian body temperature rhythm. Neurosci Lett 192: 1-4, 1995.
37. Verhoef P, Stampfer MJ, Buring JE, et al. Homocysteine metabolism and risk of myocardial infarction: Relation with vitamin B6, B12, and folate. Am J Epidemiol 143:9:845-59, 1996.
38. Wright J.V. Treatment of childhood asthma with parenteral vitamin B12, gastric reacidification, and attention to food allergy, magnesium and pyridoxine: Three case reports with background and an integrated hypothesis. J Nutr Med 1: 277-82, 1990.

 

Sources
Joseph E. Pizzorno Jr., Michael T. Murrey & Melvyn R. Werbach.

Vitamin C, Research references

January1999

1. Anderson R, Oosthuizen R, Maritz R et al. Effects of increasing weekly doses of ascorbate on certain cellular and humoral immune functions in normal volunteers. Am J Clin Nutr 33: 71-76, 1980.
2. Atkins GL et al. Quantitative aspects of ascorbic acid metabolism in man. J Biol Chem 239:2975-80, 1964.
3. Baetgen D. Results of the treatment of epidemic hepatitis in children with high doses of ascorbic acid in the years 1957 – 1958. Medizinische Monatschrift 15:30-36, 1961 (in German).
4. Baird IM et al. The effects of ascorbic acid and flavonoids on the occurrence of symptoms normally associated with the common cold. Am J Clin Nutr 32: 1686-90, 1979.
5. Baur H, Staub H. Treatment of hepatitis with infusions of ascorbic acid: Comparison with othertherapies. Abstract. JAMA 156; (5): 565, 1954.
6. Bendich A, Langseth L. The health effects of vitamin C supplementation. A review J Am Col Nutr 14: 124-136, 1995.
7. Belfield, WO, Stone, I. Megascorbic prophylaxis and megascorbic therapy: A new orthomolecular modality in veterinary medicine. Journal of the International Academy of Preventive Medicine, 2:10-26, 1975.
8. Bjelke E. Epidemiologic studies of cancer of the stomach, colon and rectum; with special emphasis on diet. Scand J Gastroenterol 9: 1-235S, 1974.
9. Block G. Vitamin C and cancer prevention. The epidemiologic evidence. Am J Clin Nutr 53: 270S-282S, 1991.
10. Blondin J et al. Prevention of eye lens protein damage by dietary vitamin C. Fed Proc 45:478, 1986.
11. Bordia A et al. Effect of vitamin C on platelet adhesiveness and platelet aggregation in coronary artery disease patients. Clin Cardiol 810:552-4, 1985.
12. Bouton SM Jr. Vitamin C and the aging eye. Arch Intern Med 63:930-45, 1939.
13. Brighthope I. AIDS – Remissions using nutrient therapies and megadose intravenous ascorbate. Int Clin Nutr Rev 7; (2):53-75, 1987.
14. Bulpitt CJ. Vitamin C and blodd pressure. J of Hypertension 12; 1071-1075, 1990.
15. Buzina R, Suboticanec K. Vitamin C and physical working capacity. Int Z VitamErnahrungsforsch (Bern) 27: 157-66, 1985; Suboticanec-Buzina K et al. Vitamin C status and physical working capacity in adolescents. Int J Vitam Min Res 54; 1: 55-60, 1984.
16. Calabrese EJ. Does exposure to environmental pollutants increase the need for vitamin C? J Environ Pathol Toxicol Oncol 1985, 5: 81-90, 1985.
17. Calleja HB, Brooks RH. Acute hepatitis treated with high doses of vitamin C. Ohio State Med J 56:821-3, 1960.
18. Cameron, E, Pauling, L. Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer. Proc. Natl. Acad. Sci. USA, 73:3685-3689, 1976.
19. Cameron, E, Pauling, L. The orthomolecular treatment of cancer: Rereviewuation of prolongation of survival times in terminal human cancer. Proc. Natl. Acad. Sci. USA, 75:4538-4542, 1978.
20. Cameron, E, Pauling, L. Cancer and Vitamin C. The Linus Pauling Institute for Science and Medicine, Menlo Park, 1979.
21. Campbell, GD Jr., Steinberg, MH and Bower, JD. Ascorbic acid induced hemolysis in G-6-PD deficiency. Ann. Int. Med. 82:810, 1975.
22. Carr AB, Einstein R, Lai LYC, et al. Vitamin C and the common cold: Using identical twins as controls. Med J Aust 2: 8: 411-12, 1981.
23. Cathcart, RF. Clinical trial of vitamin C. Medical Tribune, June 25, 1975.
24. Cathcart, RF. Clinical use of large doses of ascorbic acid. Presented at the annual meeting of the California Orthomolecular Medical Society, San Francisco, February 19, 1976.
25. Cathcart, RF. Vitamin C as a detoxifying agent. Presented at the annual meeting of the Orthomolecular Medical Society, San Francisco, January 21, 1978.
26. Cathcart, RF. Vitamin C – The missing stress hormone. Presented at the annual meeting of the Orthomolecular Medical Society, San Francisco, March 3, 1979.
27. Cathcart, RF. The method of determining proper doses of vitamin C for the treatment of disease by titrating to bowel tolerance. J. Orthomolecular Psychiatry, 10:125-132, 1981.
28. Cathcart RF III. Vitamin C in the treatment of acquired immune deficiency syndrome (AIDS). Med Hypotheses 14; 4:423-33, 1984.
29. Cathcart RF 3rd. Glutathione and HIV infection. Letter. Lancet i:235, 1990; Cathcart RF 3rd. Vitamin C in the treatment of acquired immune deficiency syndrome (AIDS). Med Hypotheses 14; (4):423-33, 1984.
30. Cathcart, RF. The third face of vitamin C. J Orthomol Med 7: 197-200, 1992.
31. Chakrabarty S, Nandi A, Mukhopadhyay C, et al. Protective role of ascorbic acid against lipid peroxidation and myocardial injury. Mol Cell Biochem 111:41-7, 1992.
32. Chamiec T et al. Effects of antioxidant vitamins C and E on signal-averaged electrocardiogram and acute myocardial infarction. Am J Cardiol 77:237-41, 1996.
33. Chandra DB, Varma R, Ahmad S et al. Vitamin C in the human aqueous humor and cataracts. Int J Vit Nutr Res 56: 165 168, 1986.
34. Chandra DB et al. Vitamin C in the human aqueous humor and cataracts. Int J Vitam Nutr Res 56:165-9, 1986.
35. Cheraskin E, Ringsdorf WM Jr, Michael DW et al. Daily vitamin C consumption and reported respiratory findings. Int J Vit Nutr Res 43: 42-55, 1973.
36. Cheraskin E, Ringsdorf WM Jr. Vitamin C and chronologic versus bone age. J Tenn Dent Assoc  57: 177-178, 1974.
37. Cheraskin E, Ringsdorf WM Jr, Medford FH. Daily vitamin C consumption and fatigability. J Am Geriatr Soc 24; (3): 136-7, 1976.
38. Cheraskin E, Ringsdorf WM Jr, Medford FH. The ‘ideal’ daily vitamin C intake. J Med Assoc State Alabama  46: 39-40, 1977.
39. Choi ESK et al. Correlation of plasma ascorbic acid with cardiovascular risk factors. Am J Clin Nutr 51:511, 1990.
40. Cheraskin E, Ringsdorf WM Jr, Sisley EL. The vitamin C connection. New York: Harper & Row. p 1-279, 1983.
41. Cook JD, Watson SS, Simpson KM et al. The effect of high ascorbic acid supplementation on body iron stores. Blood 64: 721-726, 1984.
42. Cousins, N. Anatomy of an Illness as Perceived by the Patient. W.W. Norton & Company, New York, 1979.
43. Cunningham J. Reduced Mononuclear Leukocyte Ascorbic Acid Content in Adults with Insulin-Dependent Diabetes Mellitus Consuming Adequate Dietary Vitamin C. Metabolism 40: 146-49, 1991.
44. Cunningham JJ, Mearkle PL and Brown RG. Vitamin C: An Aldose Reductase Inhibitor that Normalizes Erythrocyte Sorbitol in Insulin-Dependent Diabetes Mellitus. J Am Coll Nutr 4: 344-50, 1994.
45. Curhan GC, Willett WC, Rimm EB, Stampfer MJ. A prospective study of the intake of vitamins C and B6, and the risk of kidney stones in men. J Urol 155:61847-51, 1996.
46. Dallal GE et al. Ascorbic acid, HDL cholesterol, and apolipoprotein A-I in an elderly Chinese population in Boston. J Am Coll Nutr 8;1:69-74, 1989.
47. Davie Sj, Gould BJ and Yudkin JS. Effect of Vitamin C on Glycosylation of Proteins. Diabetes 41: 167-73, 1992.
48. Dawson EB. Relationship between ascorbic acid and male fertility. World Review of Nutrition and Dietetics 62; 1-26, 1990.
49. Devamanoharan P et al. Prevention of selenite cataract by vitamin C. Exp Eye Res 52:563-8, 1991.
50. Dobson HM et al. The effect of ascorbic acid on the seasonal variations in serum cholesterol levels. Scot Med J 293:176-82, 1984.
51. Eaton SB, Shostak M, Konner M. The paleolithic prescription. New York: Harper & Row. p 82,130-131, 1988.
52. Emstrom JE, Kanim LE, Klein MA. Vitamin C intake and mortality among a sample of the United States population. Epidem 3: 194-202, 1992.
53. Enstrom JE, Kanim LE, Klein MA. Vitamin C intake and mortality among a sample of the United States population. Epidemiology 3:3:194-202, 1992.
54. Erden F, Gulenc S, Torun M et al. Ascorbic acid effect on some lipid fractions in human beings. Acta Vitaminol Enzymol 7: 131-138, 1985.
55. Eriksson J, Kohvakka A. Magnesium and ascorbic acid supplementation in diabetes mellitus. Ann Nutr Metab 394:217-23, 1995.
56. Esk C et al. Correlation of plasma ascorbic acid with cardiovascular risk factors. Clin Res 38:A747, 1990.
57. Fontham ET, Pickle LW, Haenszel W et al. Dietary vitamins A and C and lung cancer risk in Louisiana. Cancer 62: 2267-2273, 1988.
58. Fraga CG. Ascorbic acid protects against endogeneous oxidative DNA damage in human sperm. Proceedings of the National Academy of Sciences 88; 11003-6, 1991.
59. Freudenheim JL, Johnson NE, Smith EL. Relationships between usual nutrient intake and bone-mineral content of women 35-65 years of age. longitudinal and cross-sectional analysis. Am J Clin Nutr 44: 863-876, 1986.
60. Gaby SK, Singh VN. Vitamin intake and health: A scientific review. New York: Marcel Dekker. p 103-161, 1991.
61. Gatto LM, Hallen GK, Brown AJ, Samman S. Ascorbic acid induces a favorable lipoprotein profile in women. J Am Coll Nutr 152:154-8, 1996.
62. Gey KF. Scientific evidence for dietary targets in europe bibliotheca nutr deta, vol. 37. Basil: Karger, 1986.
63. Gey KF, Stahelin HB, Eichholzer M. Poor plasma status of carotene and vitamin C is associated with higher mortality from ischemic heart disease and stroke: Basel Prospective Study. Clin Invest 71:3-6, 1993.
64. Ginter E. Cholesterol: Vitamin C controls its transformation to bile acids. Science 179; (74):702-4, 1973.
65. Ghosh J, Das S. reviewuation of vitamin A and C status in normal and malignant conditions and their possible role in cancer prevention. Jpn J Cancer Res 76: 1174-1178, 1985.
66. Ginter E, Cerna O, Budlovsky J et al. Effect of ascorbic acid on plasma cholesterol in humans in a long-term experiment. Int J Vit Nutri Res 47: 123-134, 1977.
67. Ginter E et al. Vitamin C in the control of hypercholesterolemia in man. Int J Vitam Nutr Res Suppl 23:137-52, 1982.
68. Greco AM, Gentile M, DiFilippo O et al. Study of blood vitamin C in lung and bladder cancer patients before and after treatment with ascorbic acid. A preliminary report. Acta Vitaminol Enzymol 4: 155-162, 1982.
69. Greenwood, J. Optimum vitamin C intake as a factor in the preservation of disc integrity. Medical Annals of the District of Columbia, 33:274-276, 1964.
70. Gustafsson U et al. The effect of vitamin C in high doses on plasma and biliary lipid composition in patients with cholesterol gallstones: Prolongation of the nucleation time. Eur J Clin Invest 27:387-91, 1997.
71. Hallberg L, Rossander L. Absorption of iron from Western-type lunch and dinner meals. Am J Clin Nutr 35: 502-509, 1982.
72. Hallfrisch J et al. High plasma vitamin C associated with increased plasma HDL- and HDL 2 -cholesterol. Clin Res 39: A203, 1991.
73. Hallfrisch J, Singh VN, Muller DC, et al. High plasma vitamin C associated with high plasma HDL-and HDL2 cholesterol. Am J Clin Nutr 60:100-5, 1994.
74. Harakeh S, Jariwalla RJ, Pauling L. Suppression of human immunodeficiency virus replication by ascorbate in chronically and acutely infected cells. Proc Natl Acad Sci USA 87; (18):7245-9, 1990.
75. Harakeh S, Jariwalla RJ. Comparative study of the anti-HIV activities of ascorbate and thiol-containing reducing agents in chronically HIV-infected cells. Am J Clin Nutr 54:1231S-5S, 1991.
76. Harakeh S, Jariwalla RJ. Ascorbate Effect on Cytokine Stimulation of HIV Production, Nutrition 11, Suppl. 5: 684-7, 1995.
77. Herbaczynska-Cedro K, Klosiewicz-Wasek B, Cedro K, et al. Supplementation with vitamins C and E suppresses leukocyte oxygen free radical production in patients with myocardial infarction. Eur Heart J 16:1044-9, 1995.
78. Hemilä H. Vitamin C and the common cold. Br J Nutr 67:3-16, 1992.
79. Hemilä H. Vitamin C and plasma cholesterol. Crit Rev Food Sci Nutr 32: 33-57, 1992.
80. Hemilä H. Does vitamin C alleviate symptoms of the common cold? – a review of current evidence. Scand J Infect Dis 26:1-6, 1994.
81. Hemilä H, Herman ZS. Vitamin C and the common cold: A retrospective analysis of Chalmers’ review. J Am Coll Nutr14; (2):116-23, 1995.
82. Hemilä H. Vitamin C supplementation and common cold symptoms: Problems with inaccurate reviews. Nutrition 12; (11-1):804-9, 1996.
83. Hemilä H. Vitamin C and common cold incidence: A review of studies with subjects under heavy physical stress. Int J Sports Med 17; 5: 370-83, 1996.
84. Hemilä H. Vitamin C, the placebo effect, and the common cold: a case study of how preconceptions influence the analysis of results. J Clin Epidemiol 49; 10: 1079-84, 1996.
85. Hemilä H. Vitamin C intake and susceptibility to the common cold. Br J Nutr 77:1-14, 1997.
86. Henson DE. Ascorbic acid: Biologic functions and relation to cancer. J of Nat Cancer Inst 83; 8; 547-550, 1991.
87. Horsey J, Livesley B, Dickerson JW. Ischemic heart disease and aged patients: Effects of ascorbic acid on lipoproteins. J Hum Nutr 35:1:53-8, 1981.
88. Hovi T et al. Topical treatment of recurrent mucocutaneous herpes with ascorbic acid-containing solution. Antivi Res 27; (3):263-70, 1995.
89. Howard PA and Meyers DG, Effect of Vitamin C on Plasma Lipids Pharmacother 29; 1129-36, 1995.
90. Hume R, Weyers E. Changes in leucocyte ascorbic acid during the common cold. Scot Med J 18:3-7, 1973.
91. Jacques PF et al. Ascorbic acid, HDL, and total plasma cholesterol in the elderly. J Am Coll Nutr 6;2:169-74, 1987.
92. Jacques PF. Effects of vitamin C on high-density lipoprotein cholesterol and blood pressure. J Am Coll Nutr 11;2:139-44, 1992.
93. Jacques PF et al., Ascorbic Acid and Plasma Lipids, Epidemiol 5; 19-26, 1994.
94. Jacques PF, Sulsky SI, Perrone GA, Schaefer EJ. Ascorbic acid and plasma lipids. Epidemiology 5:19-24, 1994.
95. Jacques PF, Sulsky SI, Perrone GE, et al. Effect of vitamin C supplementation on lipoprotein cholesterol, apolipoprotein, and triglyceride concentrations. Ann Epidemiol 51:52-9, 1995.
96. Jenkins SA. Vitamin C and gallstone formation: A preliminary report. Experientia 33:1616-17, 1977.
97. Jenkins SA. Biliary lipids, bile acids and gallstone formation in hypovitaminotic C guinea-pigs. Br J Nutr 40:317-22, 1978.
98. Jenkins SA. Vitamin C status, serum cholesterol levels and bile composition in the pregnant guinea-pig. Br J Nutr 43:1:95-100, 1980.
99. Jialal I, Vega Gl, Grundy SM. Physiologic levels of ascorbate inhibit the oxidative modification of low density lipoprotein. Atherosclerosis 82:185-91, 1990.
100. Johnston CS, Luo B. Comparison of the absorption and excretion of three commercially available sources of vitamin C. J Am Dietetic Assoc 94: 779-781, 1994.
101. Kennes B, Dumont 1, Brohee D et al. Effect of vitamin C supplements in cell-mediated immunity in old people. Gerontology 29: 310, 1983.
102. Khaw K-T, et al. Lancet, Vol. 357; 9257: p. 657-663, 2001
103. Khaw K-T, Woodhouse P. Interrelation of vitamin C, infection, hemostatic factors and cardiovascular disease. BMJ 310:1559-63, 1995.
104. Kinsman RA, Hood J. Some behavioral effects of ascorbic acid deficiency. Am J Clin Nutr 24; (4): 455-64, 1971.
105. Klenner, FR. Virus pneumonia and its treatment with vitamin C. J. South. Med. and Surg., 110:60-63, 1948.
106. Klenner, FR. The treatment of poliomyelitis and other viral diseases with vitamin C. J. South. Med. and Surg., 111:210-214, 1949.
107. Klenner FR. Observations on the dose of administration of ascorbic acid when employed beyond the range of a vitamin in human pathology. J Appl Nutr 23; (3&4):61-88, Winter, 1971.
108. Klenner, FR. Significance of high daily intake of ascorbic acid in preventive medicine. J. Int. Acad. Prev. Med., 1:45-49, 1974.
109. Krumdieck C, Butterworth CE Jr. Ascorbate-cholesterollecithin interactions. Factors of potential importance in pathogenesis of atherosclerosis. Am J Clin Nutr 27: 866-876, 1974.
110. Krystal G et al. Stimulation of DNA synthesis by ascorbate in culture of articular chondrocytes. Arthritis Rheum 25: 318-25, 1982.
111. Kune S, Kune GA, Watson LF. Case-control study of dietary etiological factors. The Melbourne Colorectal cancer study. Nutr Cancer 9: 21-42, 1987.
112. Lamden MP, Chrystowski GA. Urinary oxalate excretion by man following ascorbic acid ingestion. Proc Soc Exp Biol Med 85:190-2, 1954.
113. Levine GN, Frei B, Koulouris SN, et al. Ascorbic acid reverses endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation 93:6:1107-13, 1996.
114. Levine M, Rumsey S, Wang Y, Park J et al. Vitamin C. In: Present knowledge in nutrition. 7th edn. Washington DC: International Life Sciences Press. p 146-159, 1996.
115. Lewin, S. Vitamin C: Its Molecular Biology and Medical Potential. Academic Press, London, 1976.
116. Li ZY et al. Amelioration of photic injury in rat retina by ascorbic acid: A histopathologic study. Invest Ophthalmol Vis Sci 26:11:1589-98, 1985.
117. Libby, AF and Stone, I. The hypoascorbemia-kwashiorkor approach to drug addiction therapy: A pilot study. J. Orthomolecular Psychiatry, 6:300-308, 1977.
118. Lohmann W. Ascorbic acid and cataract. Ann NY Acad Sci 498: 307-311, 1987.
119. Losonczy KG, Harris TB, Havlik RJ. Vitamin E and vitamin C supplement use and risk of all-cause and coronary heart disease mortality in older persons: the Established Populations for Epidemiologic Studies of the Elderly. Am J Clin Nutr 64:190-6, 1996.
120. Lu SH, Otishima H, Fu HM, Tian Y, Li FM, Blettner M, Wahrendorf J, Bortsch H. Urinary excretion of N-nitrosamino acids and nitrate by inhabitants of high and low-risk areas of esophageal cancer in Northern China. Endogenous formation of nitrosoproline and its inhibition by vitamin C. Cancer Res 46: 1485-1491, 1986.
121. Marshall J, Graham S, Mettlin C et al. Diet in the epidemiology of oral cancer. Nutr Cancer 3: 145-149, 1982.
122. Mena MA, Pardo B, Paino CL, et al. Levodopa toxicity is foetal rat midbrain neurones in culture: Modulation by ascorbic acid. Neuro Rep 4:438-40, 1993.
123. Mezzetti A, Lapenna D, Pierdomenico SD, et al. Vitamins E, C and lipid peroxidation in plasma and arterial tissue of smokers and nonsmokers. Atherosclerosis 112:91-9, 1995.
124. Moran JP, Cohen L, Greene JM et al. Plasma ascorbic acid concentrations relate inversely to blood pressure in human subjects. Am J Clin Nutr 57: 213-217, 1993.
125. Morishige F, Murata A. Vitamin C for prophylaxis of viral hepatitis B in transfused patients. J Int Coll Prev Med 5; (1):54-58, 1978.
126. Muhlmann V et al. Vitamin C therapy of incipient senile cataract. Arch Oftalmol B Aires 14:552-75, 1939.
127. Mullen A, Wilson CWM. The metabolism of ascorbic acid in rheumatoid arthritis. Proc Nutr Sci 35: 8A-9A, 1976.
128. Murata, A. Virucidal activity of vitamin C: Vitamin C for the prevention and treatment of viral diseases. Proceedings of the First Intersectional Congress of Microbiological Societies, Science Council of Japan, 3:432-442, 1975.
129. Ness A, Khaw K, Bingham S, Day NE. Vitamin C status and serum lipids. Eur J Clin Nutr 50; 11:724-9, 1996.
130. Nyyssonen K et al. Vitamin C deficiency and risk of myocardial infarction: Prospective population study of men from Eastern Finland. BMJ 314:634-8, 1997.
131. O’Connor HJ, Habibzedah N, Schorah CJ et al. Effect of increased intake of vitamin C on the mutagenic activity of gastric juice and intrgastric concentrations of ascorbic acid. Carcinogenesis. 6: 1675-1676, 1985.
132. Oldroyd KG, Dawes PT. Clinically significant vitamin C deficiency in rheumatoid arthritis. Br J Rheumatol 24: 362-3, 1985.
133. Organisciak DT et al. The protective effect of ascorbate in retinal light damage of rats. Invest Ophthalmol Vis Sci 26:11:1580-8, 1985.
134. Pauling, L. Vitamin C and the Common Cold. W.H. Freeman and Company, San Francisco, 1970.
135. Pauling, L. Vitamin C, the Common Cold, and the Flu. W.H. Freeman and Company, San Francisco, 1976.
136. Ramirez J, Flowers NC. Leukocyte ascorbic acid and its relationship to coronary artery disease in man. Am J Clin Nutr 33: 2079-2087, 1980.
137. Rath M, Pauling L. Solution to the puzzle of human cardiovascular disease: Its primary cause is ascorbate deficiency leading to the deposition of lipoprotein a and fibrinogen/fibrin in the vascular wall. J Orthomol Med 6:3-4:125-34, 1991.
138. Riemersma RA, Wood DA, MacIntyre CCH, et al. Risk of angina pectoris and plasma concentrations of vitamins A, C and E and carotene. Lancet 337:1-5, 1991.
139. Ringsdorf WM Jr, Cheraskin E. Vitamin C and human wound healing. Oral Surg 53: 231-236, 1982.
140. Riemersma RA, Wood DA, Macintyre CAC et al. Vitamin E. Biochemistry and health implications, vol. 570. New York: Ann NY Acad Sci. p 291-295, 1989.
141. Ringsdorf WM Jr, Cheraskin E. Vitamin C and human wound healing. Oral Surg 53: 231-236, 1982.
142. Rivers JM. Safety of high level vitamin C ingestion. Int J Vitamin Nutr Res 30: 95-102, 1989.
143. Roberts P et al. Vitamin C and inflammation. Med Biol 62:88, 1984.
144. Romney SL, Duttagupta C, Basu J et al. Plasma vitamin C and uterine cervical dysplasia. Am J Obstet Gynecol 151: 976-980, 1985.
145. Sahud MA, Cohen RJ. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet i: 937-8, 1971.
146. Sahyoun NR et al. Carotenoids, vitamins C and E, and mortality in an elderly population. Am J Epidemiol 144:5:501-11, 1996.
147. Salaman, M. Fighting infection-the cat and the “C”. Let’s Live, 128-130, April 1980.
148. Schorah CJ, Scott DL, Newill A, Morgan DB. Clinical effects of vitamin C in elderly inpatients with low blood-vitamin C levels. Lancet i: 403-5, 1979.
149. Schwartz PL. Ascorbic acid in wound healing: A review. J Am Diet Assoc 56: 497-503, 1970.
150. Schwartz ER. The modulation of osteoarthritic development by vitamins C and E. Int J Vitam Nutr Res Suppl. 26: 141-6, 1984.
151. Seddon JM, Ajani UA, Sperduto RD, et al. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. JAMA 272:1413-20, 1994.
152. Shilotri PG, Bhat KS. Effect of mega doses of vitamin C on bactericidal activity of leukocytes. Am J Clin Nutr 30: 1007-1081, 1977.
153. Siegel, BV. Enhancement of Interferon Response by poly(rI).- poly(rC) in Mouse Cultures by Ascorbic Acid. Nature 254:531-532, 1975.
154. Siegel, BV, Morton, J.I. Vitamin C and the Immune Response. Experientia 33:393-395, 1977.
155. Simon JA, Vitamin C and Cardiovascular Disease: A Review, J Am Coll Nutr 11; 107-125, 1992.
156. Stone, I. Studies of a mammalian enzyme system for producing evolutionary evidence on man. Am. J. Phys. Anthro., 23:83-86, 1965.
157. Stone, I. Hypoascorbemia: The genetic disease causing the human requirement for exogenous ascorbic acid. Perspectives in Biology and Medicine, 10:133-134, 1966.
158. Stone, I. The Healing Factor: Vitamin C Against Disease. Grosset and Dunlap, New York, 1972.
159. Subramanian, N. et al. Detoxification of histamine with ascorbic acid. Biochemical Pharmacology. 27:1671-1673, 1973.
160. Sowers MR, Wallace RB and Lemke JH. Correlates of mid-radius bone density among postmenopausal women. A community study. Am J Clin Nutr 41: 1045-1053, 1985.
161. Stamler J. Nutrition, lipids and coronary heart disease. New York: Raven Press. p 25, 1979.
162. Tannenbaum SR, Wishnok JS, Leaf CD. Inhibition of nitrosamine formation by ascorbic acid. Am J Clin Nutr 53: 247S-250, 1991.
163. Terezhalmy GT, Bottomley WK, Pelleu GB. The use of water-soluble bioflavonoid-ascorbic acid complex in the treatment of recurrent herpes labialis. Oral Surg Oral Med Oral Pathol 45; (1):56-62, 1978.
164. Tomoda H, Yoshitake M, Morimoto K, Aoki N, et al. Possible prevention of postangioplasty restenosis by ascorbic acid. Am J Cardiology 78;11:1284-6, 1996.
165. Toohey L et al. (Low) Plasma ascorbic acid concentrations are related to cardiovascular risk factors in African-Americans. J Nutr 126:121-8, 1996.
166. Turley S et al. Role of ascorbic acid in the regulation of cholesterol metabolism and the pathogenesis of atherosclerosis. Atherosclerosis 24:1-18, 1976.
167. Vallance BD, Hume R, Weyers E. Reassessment of changes in leucocyte and serum ascorbic acid after acute myocardial infarction. Br Heart J 40;1:64-8, 1978.
168. Varma SD, Richards RD. Light-induced damage to ocular lens cation pump: Prevention by vitamin C. Proc Natl Acad Sci U S A 76: 3504-6, 1979.
169. Varma SD et al. Photoperoxidation of lens lipids: Prevention by vitamin E. Photochem Photobiol 36:6:623-36, 1982.
170. Varma SD. Ascorbic acid and the eye with special reference to the lens, in JJ Burns, JM Rivers, LJ Machlin, Eds. Third Conference on Vitamin C. New York, New York Academy of Sciences 498: 280-306, 1987.
171. Vinson JA et al. In Vitro and in Vivo Reduction of Erythrocyte Sorbitol by Ascorbic Acid. Diabetes 38: 1036-41, 1989.
172. Vitale S et al. Plasma vitamin C, E and beta carotene levels and risk of cataract. Invest Ophthalmol Vis Sci 32:723, 1991.
173. Wandzilak TR, D’andre SD, Davis PA, Williams HE. Effect of high dose vitamin C on urinary oxalate levels. J Urol 151:834-837, 1994.
174. Wartamowicz M, Panczenko-Kresowka B, Ziemlaski S et al. The effect of alpha-tocopherol and ascorbic acid on the serum lipid peroxide level in elderly people. Ann Nutr Metabol 28: 186-191, 1984.
175. Wassertheil-Smoller S, Romney SC, Wylie-Rosett J et al. Dietary vitamin C and uterine cervical dysplasia. Am J Epidemiol 114: 714-724, 1981.
176. Weisburger J. Nutritional approach to cancer prevention with emphasis on vitamins, antioxidants, and carotenoids. Am J Clin Nutr 53: S226-237, 1991.
177. Weisburger JH. Vitamin C and disease prevention. J Am Col Nutr 14: 109-111, 1995.
178. Will EJ, Bijvoet OL. Primary oxalosis: Clinical and biochemical response to high-dose pyridoxine therapy. Metabolism 28; 5:542-548, 1979.
179. Williams, RJ. The Prevention of Alcoholism Through Nutrition. Bantam Books, New York, 1981.
180. Williams, RJ. Biochemical Individuality. John Wiley, New York, 1956. University of Texas Press, Austin, Texas, 1973.
181. Yapa S. Detection of subclinical ascorbate deficiency in early Parkinson’s disease. Public Health 106:393-5, 1992.
182. Yoshioka M, Matsushita T, Chuman Y. Inverse association of serum ascorbic acid level and blood pressure or rate of hypertension in male adults aged 30-39 years. Int J Vit Nutr Res 54: 343-347, 1984.
183. Ziemlanski S, Wartanowicz M, Potrzebnicka K et al. Ascorbic acid and tocopherol levels in the organs and serum of guinea pigs with experimentally induced atherosclerosis. Acta Physiol Pol 40: 552-557, 1989.
184. Zureick M. Treatment of shingles and Herpes with Vitamin C intravenously. J des Praticiens 64:586, 1950.


Sources

Joseph E. Pizzorno Jr., Michael T. Murrey & Melvyn R. Werbach.

Vitamin D, Research references

January 1999

1. Anonymous. Vitamin D supplementation in the elderly Lancet 1: 306-307, 1987.
2. Chapuy MC, Chapuy P, Mennier PJ. Calcium and vitamin D supplements. Effects on calcium metabolism in elderly people. Am J Clin Nutr 46: 324-328, 1987.
3. Chapuy MC, Arlot ME, Duboeuf F et al. Vitamin D3 and calcium to prevent hip fractures in elderly women. N Engl J Med 327: 1637-1642, 1992.
4. Crombie IK. Distribution of malignant melanoma on the body surface. Br J Cancer 43: 842-849, 1981.
5. Gaby SK, Singh VN. Vitamin intake and health: A scientific review. New York: Marcel Dekker. p 59-70, 1990.
6. Garland CF, Garland FC. Do sunlight and vitamin D reduce the likelihood of colon cancer? Int J Epidemiol 9: 227-231, 1980.
7. Garland C, Shekelle RB, Barrett-Connor E et al. Dietary vitamin D and calcium and risk of colorectal cancer. Lancet 1: 307-309, 1985.
8. Garland CF, Comstock GW, Garland FC et al. Serum 25-hydroxy vitamin D and colon cancer. Lancet 2: 1176-1178, 1989.
9. Garland FC, Garland CF, Gorham ED et al. Geographic variation in breast cancer mortality in the United States. A hypothesis involving exposure to sular radiation. Arch Environ Health 45: 261-267, 1990.
10. Garland CF, Gorham ED, Young JF. Geographic variation in breast cancer mortality in the United States: A hypothesis involving exposure to solar radiation. Prevent Med 19: 614-622, 1990.
11. Haug S, Muller F, Aukrust P, et al. Subnormal serum concentrations of 1,25-vitamin D in human immunodeficiency virus infection: Correlation with degree of immune deficiency and survival. J Infect Dis 169:889-92, 1994.
12. Koh HK, Kligler BE, Lew RA. Sunlight and cutaneous malignant melanoma. Evidence for and against causation. Photochem Photobiol.19: 614-622, 1990.
13. Kroger H, Penttila I, Alhava E. Low serum vitamin D metabolites in women with rheumatoid arthritis. Scand J Rheumatol 22: 172-7, 1993.
14. Lips P, van Ginkel FC, Jongen MJ et al. Determinants of Vitamin D status in pahents with hip fracture and in elderly control subject. Am J Clin Nutr 46: 1005-1010, 1987.
15. MacLaughlin J, Holick MF. Aging decreases the capacity of human skill to produce vitamin D3. J Clin Invest; 76: 1536-1538, 1985.
16. McAlindon T, Felson D, Zhang Y, et al. Relation of dietary intake and serum levels of vitamin D to progression of osteoarthritis of the knee among participants in the Framingham study. Ann Intern Med 125; 5: 353-9, 1996.
17. Norman AW. Vitamin D. In: Present knowledge in nutrition.7th edn.Washington DC: International Life Sciences Press. p 120-129, 1996.
18. Omdahl JL, Garry PJ, Hunsaker LA et al. Nutritional status in a healthy elderly population: Vitamin D Nutritional status in a healthy elderly population: Vitamin D. Am J Clin Nutr 36: 1225-1233, 1982.
19. Parfitt AM, Gallagher JC, Heaney RP et al. Vitamin D and bone health in the elderly. Am J Clin Nutr 36: 1014-1031, 1982.
20. Reed A et al. 25-hydroxy vitamin D therapy in children with active juvenile rheumatoid arthritis: Short-term effects on serum osteocalcin levels and bone mineral density. J Pediatr 119; (4): 657-60, 1991.
21. Sowers MR, Wallace RB, Lemke JH. The association of intakes of vitamin D and calcium with blood pressure among women. Am J Clin Nutr 42: 135-142, 1985.
22. Sowers MF, Wallace RB, Hollis BW et al. Relationship between 1,25-dihydroxy vitamin D and blood pressure in our geographically defined population. Am J Clin Nutr 48: 1053-1056, 1988.
23. Vagero R, Ringback G, Kiveranta H. Vagero Melanoma and other tumors of the skin among office, other outdoor/indoor workers in Sweden. Br J Cancer 53: 507-512, 1986.
24. Webb AR, Holick MF. Influence of season and latitude on cutaneous synthesis of vitamin D3. Ann Rev Nutr 8: 375-399, 1988.
25. Wiedmann KH, Brattig NW, Diao GD et al. Serum inhibiting factors (SIF) are of prognostic value in acute viral hepatitis. Lancet i: 307-309, 1985.

 

Sources
Joseph E. Pizzorno Jr., Michael T. Murrey & Melvyn R. Werbach.

Vitamin E, Research references

January 1999

1. Ackerman Z et al. Neurological manifestations in celiac disease and vitamin E. J Clin Nutr 11; 5: 603-5, 1989.
2. Anderson TW et al. A double-blind trial of vitamin E in angina pectoris. Am J Clin Nutr 27:1174-8, 1974.
3. Adayeva Y et al. Vitamin E treatment in dystrophy of the macula lutea. Am J Ophthalmol 56:498, 1963.
4. Ayres S, Ihan R. Post-herpes Zoster neuralgia: Response to Vitamin E Therapy. Arch Dermatol 108:855-6, 1973.
5. Ayres S, Mihan R. Is vitamin E involved in the autoimmune mechanism? Cutis 21: 321-5, 1978.
6. Barboriak JJ et al. Vitamin E supplements and plasma high-density lipoprotein cholesterol. Am J Clin Pathol 77;3:371, 1982.
7. Bellizzi MC, Franklin MF, Duthie GG, et al. Vitamin E and coronary heart disease: The European paradox. Eur J Clin Nutr 48:822-31, 1994.
8. Bendich A, Machlin LJ. Safety of oral intake of vitamin E. Am J Clin Nutr 48: 612-619, 1988.
9. Bierenbaum M et al. Relationship between serum lipid peroxidation products in hypercholesterolemic subjects and vitamin E status. Biochem Int 28:57-66, 1992.
10. Blankenhorn G. Vitamin E: Clinical research from Europe. Nutr Dietary Consult June, 1988.
11. Bruce A et al. The effect of selenium and vitamin E on glutathione peroxidase levels and subjective symptoms in patients with arthrosis and rheumatoid arthritis, in Proc N Z Workshop on Trace Elements in N Z. Dunedin, U. of Otago, 92, 1981.
12. Block MT. Vitamin E in the treatment of diseases of the skin. Clin Med January pp. 31-4, 1953.
13. Burgess JF, Pritchard JE. Tocopherol (vitamin E) treatment of lupus erythematosus: Preliminary report. Arch Dermatol Syphilol 57: 953, 1948.
14. Burton GW, Ingold KU. Vitamin E as an in vitro and in vivo antioxidant. In: Diplock AT, Machoin LJ, Parker L, Pryor WA, eds. Vitamin E: Biochemistry and health implications. Ann NY Acad Sci 570: 7-22, 1989.
15. Carpenter KLH et al. Depletion of alpha-tocopherol in human atherosclerotic lesions. Free Rad Res 23:549- 58, 1995.
16. Cavarocchi NC et al. Superoxide generation during cardiopulmonary bypass: Is there a role for vitamin E? J Surg Res 40:519-27, 1986.
17. Chamiec T et al. Effects of antioxidant vitamins C and E on signal-averaged electrocardiogram and acute myocardial infarction. Am J Cardiol 77:237-41, 1996.
18. Chavance M. Nutrition, immunity, and illness in the elderly. New York: Pergamon Press. p 137-142, 1985.
19. Cheraskin E, Ringsdorf WM, Jr. Nutr Rep Int 2: 107-117, 1970.
20. Cloarec MJ et al. Alpha-tocopherol: Effect on plasma lipoproteins in hypercholesterolemic patients. Isr J Med Sci 23;8:869-72, 1987.
21. Cochrane T. Post-herpes Zoster neuralgia: Response to Vitamin E Therapy. Letter. Arch Dermatol 111:396, 1975.
22. Coghlan JG, Flitter WD, Clutton SM, et al. Lipid peroxidation and changes in vitamin E levels during coronary artery bypass grafting. J Thorac Cardiovasc Surg 106;2:268-74, 1993.
23. Comstock GW et al. Serum concentrations of alpha-tocopherol, beta-carotene, and retinol preceding the diagnosis of rheumatoid arthritis and systemic lupus erythematosus. Ann Rheum Dis 56: 323-5, 1997.
24. Creighton MO, Trevitchick JR. Cortical cataract formation prevented by vitamin E and glutathione. Exp Eye Res 29:6:689-93, 1979.
25. Creighton MO et al. Modelling cortical cataractogenesis: V. Steroid cataracts induced by Solu-medrol partially prevented by vitamin E in vitro. Exp Eye Res 37:1:65-76, 1983.
26. Creter D et al. Effect of vitamin E on platelet aggregation in diabetic retinopathy. Acta Hematol 62:74, 1979.
27. DeMaio SJ et al. Vitamin E supplementation, plasma lipids and incidence of restenosis after percutaneous transluminal coronary angioplasty PTCA. J Am Coll Nutr 11;1:68-73, 1992.
28. Dieber-Rotheneder M et al. Effect of oral supplementation with D-alpha-tocopherol on the vitamin E content of human low density lipoproteins and resistance to oxidation. J Lipid Res 32:1325- 32, 1991.
29. DiMascio P, Murphy M, Sies H. Antioxidant and defense systems. The role of carotenoids, tocopherols and thiols. Am J Clin Nutr 53: S194-200, 1991.
30. Dimitrov NV et al. Plasma tocopherol concentrations in response to supplements vitamin E. Am J Clin Nutr 1991; 53: 723-729, 1991.
31. Diplock AT, Machlin LJ, Packer L et al, eds. Daily vitamin E consumption and reported cardiovascular findings. New York: Ann NY Acad Sci. 1989: p 1-535, 1989.
32. Eldred GE. Vitamins A and E in RPE lipofuscin formation and implications for age-related macular degeneration. Prog Clin Biol Res 314:113-29, 1989.
33. Esterbauer H, Dieber-Rotheneder M, Striegl G et al. Role of vitamin E in preventing the oxidation of low-density lipoprotein. Am J Clin Nutr 1991; 53: 314S-321S.
34. Fahn S. A pilot trial of high-dose alpha-tocopherol and ascorbate in early Parkinson’s disease. Ann Neurol 32:S128-32, 1992; Fahn S. An open trial of high-dosage antioxidants in early Parkinson’s disease. Am J Clin Nutr 53:380S-1S, 1991.
35. Factor SA, Sanchez-Ramos JR, Weiner WJ. Vitamin E therapy in Parkinson’s disease. Adv Neurol 53:457-61, 1990.
36. Ferreira R et al. Antioxidant action of vitamins A and E in patients submitted to coronary bypass surgery. Vasc Surg 25:191-5, 1991.
37. Fink M, Fink J. Treatment of herpes simplex by alpha-tocopherol (Vitamin E). Br Dent J 148:246, 1980.
38. Fong JSC. Alpha-tocopherol. Its inhibition on human platelet aggregation. Experientia 32: 639-641, 1976.
39. Gaby WK et al. Vitamin intake and health: A scientific review. New York: Marcel Dekker. 1991: p 71-101.
40. Gey KF. Inverse correlation between plasma vitamin E and mortality from ischemic heart disease in cross-cultural epidemiology. Am J of Clin Nutr 53 (suppl.1); 326S-34S, 1991.
41. Giani E et al. Heated fat; vitamin E and vascular eicosanoids. Lipids 20: 439-448, 1985.
42. Haenszel W, Correa P, Lopez A et al. Serum micronutrient levels in relation to gastric pathology. Int J Cancer 36: 43-48, 1985.
43. Hayes KC. Retinal degeneration in monkeys induced by deficiencies of vitamin E or A. Invest Ophthalmol Vis Sci 13:7:499-510, 1974.
44. Hennig B et al. Protective effects of vitamin E in age-related endothelial cell injury. Int J Vitam Nutr Res 59:273-9, 1989.
45. Herbaczynska-Cedro K, Klosiewicz-Wasek B, Cedro K, et al. Supplementation with vitamins C and E suppresses leukocyte oxygen free radical production in patients with myocardial infarction. Eur Heart J 16: 1044-9, 1995.
46. Hermann WJ et al. The effect of tocopherol on high-density lipoprotein cholesterol: A clinical observation. Am J Clin Pathol 72:848-52, 1979.
47. Honkanen V et al. Vitamins A and E, retinol binding protein and zinc in rheumatoid arthritis. Clin Exp Rheumatol 7: 465-9, 1989.
48. Honkanen VEA et al. Serum cholesterol and vitamins A and E in juvenile chronic arthritis. Clin Exp Rheumatol 8: 187-91, 1990.
49. Horwitt MK. Supplementation with vitamin E. Am J Clin Nutr 47: 1088-1089, 1988.
50. Hu JJ et al. Effects of dietary supplementation of alpha-tocopherol on plasma glutathione and DNA repair activities. Canc Epidemiol Biomark Preven 5; (4): 263-70, 1996.
51. Jacques PF. Chylack antioxidant status in persons with and without senile cataract. Arch Ophthalmol 106: 337-340, 1988.
52. Jain SK, McVie R, Jaramillo JJ, et al. The effect of modest vitamin E supplementation on lipid peroxidation products and other cardiovascular risk factors in diabetic patients. Lipids 31:S87-90, 1996.
53. James S et al. Effekter av selenvitamin E-behandling till kvinnor med lång variga arbetsrelaterade nack-och skuldersmärtor. En dubbelblindstudie. Läkaresällskapets Riksstämma, 1985.
54. Jandak J et al. Reduction of platelet adhesiveness by vitamin E supplementation in humans. Thrombosis Res 49:393-404, 1988.
55. Jandak J et al. Alpha tocopherol, an effective inhibitor of platelet adhesion. Blood 73:141-9, 1989.
56. Jialal I, Grundy SM. Effect of dietary supplementation with alpha-tocopherol on the oxidative modification of low density lipoprotein. J Lipid Res 33;6:899-906, 1992.
57. Jialal L, Fuller CJ, Hunt BA. The effect of alpha-tocopherol supplementation on LDL oxidation. Arterioscler Thromb Vasc Biol 15:190-8, 1995.
58. Juhlin L et al. Blood glutathione-peroxidase levels in skin diseases: Effect of selenium and vitamin E treatment. Acta Derm Venereal (Stockh) 62; 3: 211-4, 1982.
59. Knekt P et al. Serum vitamin E level and risk of cancer among Finnish men during a 10-year follow-up. Am J Epidemiol 127: 28-41, 1988.
60. Kneckt P. Serum vitamin E level and risk of female cancers. Int J Epidem 17: 281-286, 1988.
61. Knekt P, Aromaa A, Maatela J et al. Vitamin E and cancer prevention. Am J Clin Nutr 53: 283S-286S, 1991.
62. Kok FJ, de Bruijn AM, Vermeeren R et al. Serum selenium, vitamin antioxidants, and cardiovascular mortality. N Eng J Med 316: 1416, 1987.
63. London R.S. et al. Endocrine Parameters and Alpha-Tocopherol Therapy of Patients with Mammary Dysplasia, Cancer Res 41; 3811-3, 1981.
64. London RS, et al. The Effect of Alpha-tochopherol on Premenstrual Symptomatology: A Double-blind Study. II Endocrine Correlates, J Am Col Nutr 3 : 351-6, 1984.
65. Losonczy, KG, Harris, TB, Havlik, RJ. Vitamin E and vitamin C supplement use and risk of all-cause and coronary heart disease mortality in older persons. The established populations for epidemiologic studies of the elderly. Am J Clin Nutr 64: 190-196, 1996.
66. Machlin LJ. Use and safe of elevated dosages of vitamin E in adults. Int J Vitam Nutr Res Suppl 30: 56-68, 1989.
67. Machtey I, Ouaknine, L. Tocopherol in osteoarthritis: A controlled pilot study. J Am Geriatr Soc 26: 328-30, 1978.
68. Mauro A, Orsi L, Mortara P, et al. Cerebellar syndrome in adult celiac disease with vitamin E deficiency. Acta Neurol Scand 84; 2:167-70, 1990.
69. Menkes MS, Comstock GW, Vuilleumier JP et al. Serum beta carotene vitamins A and E, selenium, and the risk of lung cancer. N Eng J Med 315: 1250-1254, 1986.
70. Meydani M et al. Muscle uptake of vitamin E and its association with muscle fiber type. Nutr Biochem 8: 74-78, 1997.
71. Mezes M, Bartosiewicz G. Investigations on vitamin E and lipid peroxide status in rheumatic diseases. Clin Rheumatol 2; 3: 259-63, 1983.
72. Mezzetti A, Lapenna D, Pierdomenico SD, et al. Vitamins E, C and lipid peroxidation in plasma and arterial tissue of smokers and nonsmokers. Atherosclerosis 112: 91-9, 1995.
73. Miwa K, Miyagi Y, Igawa A, et al. Vitamin E deficiency in variant angina. Circulation 94;1:14-18, 1996.
74. Miyamoto H, Araya Y, Ito M et al. Serum selenium and vitamin E. concentrations in families of lung cancer patients. Cancer 60: 1159-1162, 1987.
75. Muckle T, Hazir D. Variation in human blood high-density lipoprotein response to oral vitamin E megadosage. Am J Clin Pathol 91: 165-71, 1989.
76. Munthe E, Aaseth J. Treatment of Rheumatoid Arthritis with Selenium and Vitamin E. Scan J of Rheumatol 53; (suppl.): 103, 1984.
77. Nead DE. Effective vitamin E treatment for ulcerative herpetic lesions. Dent Survey 52; (7):50-1, 1976.
78. Niki E, Yamamoto Y, Komuro E et al. Membrane damage due to lipid oxidation. Am J Clin Nutr  53: S201-205, 1991.
79. Novelli GP et al. Vitamin E protects human skeletal muscle from damage during surgical ischemia-reperfusion. Am J Surg March 173: 206-9, 1997.
80. Odeleye OE, Watson RR. The potential role of vitamin E in the Treatment of immunologic abnormalities during Acquired Immune Deficiency Syndrome. Prog Food Nutr Sci 15; (1-2):1-19, 1991.
81. Pacht ER, Kaseki H, Mohammed JR et al. Deficiency of vitamin E in the alveolar fluid of cigarette smokers. J Clin Invest 77: 789-798, 1986.
82. Paolisso G et al. Cronic Intake of Pharmacological Doses of Vitamin E Might be Useful in the Therapy of Elderly Patients with Coronary Heart Disease. Am J Clin Nutr 61: 848-52, 1995.
83. Pascoe GA, Fariss MW, Olafsdottir K et al. A role of vitamin E in protection against cell injury. Maintenance of intracellular glutathione precursors and biosynthesis. Eur J Biochem 166: 241-247, 1987.
84. Prasad JS. Effect of vitamin E supplementation on leukocyte function. Am J Clin Nutr 33: 606-608, 1980.
85. Princen H, van Poppel G, Vogelezang C, et al. Supplementation with vitamin E but not beta carotene in vivo protects low density lipoprotein from lipid peroxidation in vitro: Effect of cigarette smoking. Arter Throm 12: 554-62, 1992.
86. Princen HM et al. Supplementation with low doses of vitamin E protects LDL from lipid peroxidation in men and women. Arterioscler Thromb Vasc Biol 15: 325-33, 1995.
87. Pryor WA. Can vitamin E protect humans against the pathological effects of ozone in smog? Am J Clin Nutr 53: 702-722, 1991.
88. RabinovitchR et al. Neuromuscular disorders amenable to wheat germ oil therapy. J Neurol Neurosurg Psychiatry 14: 95-100, 1951.
89. Reddy ACP, Lokesh BR. Dietary unsaturated fatty acids, vitamin E, curcumin and eugenol
90. alter serum and liver lipid peroxidation in rats. Nutr Res 14: 1423-37, 1994.
91. Regnström J, Nilsson J, Moldeus P, et al. Inverse relation between the concentration of low-density- lipoprotein vitamin E and severity of coronary artery disease. Am J Clin Nutr 63: 377-85, 1996.
92. Riemersma RA, Wood DA, MacIntyre CCH, et al. Risk of angina pectoris and plasma concentrations of vitamins A, C and E and carotene. Lancet 337: 1-5, 1991.
93. Riemersma RA, Wood DA, MacIntyre CCA et al. Low plasma vitamins E and C increased risk of angina in Scottish men. In: Diplock AT, Machlin LJ, Packer L et al, eds. Vitamin E: Biochemistry and health implications, vol. 570. New York: Ann NY Acad Sci. p 291-295, 1989.
94. Robertson JM, Donner AP, Trevithick JR. Vitamin E: Biochemistry and health implications, vol. 570. New York: Ann NY Acad Sci. p 372-382, 1989.
95. Robertson JM, Donner AP, Trevithick JR. Vitamin E intake and risk of cataracts in humans. Ann NY Acad Sci 570: 372-378, 1989.
96. Robertson JM et al. Vitamin E intake and risk of cataracts in humans. Ann N Y Acad Sci 570: 372-82, 1989.
97. Robison WG Jr et al. Vitamin E deficiency and the retina: Photoreceptor and pigment epithelial changes. Invest Ophthalmol Vis Sci 18:7:683-90, 1979.
98. Romeo G. The therapeutic effect of vitamins A and E in neurosensory hearing loss. Acta Vitaminol Enzymol 7 Suppl:85-92, 1985.
99. Ross WM et al. Modelling cortical cataractogenesis: III. In vivo effects of vitamin E on cataractogenesis in diabetic rats. Can J Ophthalmol 17:2: 61-6, 1982.
100. Ross WM et al. Radiation cataract formation diminished by vitamin E in rat lenses in vitro. Exp Eye Res 36:5: 645-53, 1983.
101. Ross WM, Creighton MO, Trevithick JR. Radiation cataractogenesis induced by neutron or gamma irradiation in the rat lens is reduced by vitamin E. Scan Micros 4: 641-50, 1990.
102. Rouhiainen P, Rouhiainen H, Salonen J, et al. Association between low plasma vitamin E concentration and progression of early cortical lens opacities. Am J Epidemiol 144: 5: 496-500, 1996.
103. Sahyoun NR et al. Carotenoids, vitamins C and E, and mortality in an elderly population. Am J Epidemiol 144:5:501-11, 1996.
104. Saito T. The preventive effect of vitamin E on gallstone formation. (1). A study of biliary cholesterol and bile acids in vitamin E-deficient hamsters. Arch Jpn Chir 56; 3: 247-61, 1987.
105. Salonen JT, Salonen R, Lappetelainen R et al. Risk of cancer in relation to serum concentrations of selenium and vitamins A and E. matched case-control analysis of prospective data. Br Med J 290: 417-420, 1985.
106. Salonen JT et al. Increased Risk of Non-Insulin Diabetes Mellitus at Low Plasma Vitamin E Concentrations: A Four-Year Follw-up Study in Men. Br Med J 311: 1124-27, 1995.
107. Schwartz ER. The modulation of osteoarthritic development by vitamins C and E. Int J Vitam Nutr Res Suppl. 26: 141-6, 1984.
108. Seddon JM, Ajani UA, Sperduto RD, et al. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. JAMA 272:1413-20, 1994.
109. Simon E et al. Plasma and erythrocyte vitamin E content in asymptomatic hypercholesterolemic subjects. Clin Chem 43:2:285-9, 1997.
110. Simons LA, Von Konigsmark M, Balasubramaniam S. What dose of vitamin E is required to reduce susceptibility of LDL to oxidation? Aust N Z J Med 26;4:496-503, 1996.
111. Sklodowska M, Wasowicz W, Gromnadzinska J, et al. Selenium and vitamin E concentrations in plasma and erythrocytes of angina pectoris patients. Trace Elem Med 8:113-17, 1991.
112. Sklodowska M et al. Vitamin E, thiobarbituric acid reactive substance concentrations and superoxide dismutase activity in the blood of children with juvenile rheumatoid arthritis. Clin Exp Rheumatol 14: 433-9, 1996.
113. Sokol RJ. Vitamin E. In: Ziegler EE, Filer LJ Jr, eds. Present knowledge in nutrition. 7th edn. Washington DC: International Life Sciences Press. p 130-136, 1996.
114. Stampfer M, Hennekens C, Manson J, et al. Vitamin E consumption and the risk of coronary heart disease in women. N Engl J Med 328:1444-9, 1993.
115. Starasoler S, Haber GS. Use of vitamin E oil in primary herpes gingivostomatitis in an adult. N Y State Dent J 44; (9):382-3, 1978.
116. Steinberg CL. Vitamin E and collagen in the rheumatic diseases. Ann N Y Acad Sci 52:380-9, 1949.
117. Steiner M. Effect of alpha-tocopherol administration on platelet function in man. Thromb Haemostas 49: 73-77, 1983.
118. Steiner M. Influence of vitamin E on platelet function in humans. J Am Coll Nutr 10;5:466-73, 1991.
119. Steiner M, Glantz M, Lekos A. Vitamin E plus aspirin compared with aspirin alone in patients with transient ischemic attacks. Am J Clin Nutr 62; suppl:1381S-4S, 1995.
120. Stephens NG, Parsons A, Schofield PM, et al. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study CHAOS. Lancet 347:781-6, 1996.
121. Stone WL et al. Effects of dietary selenium and vitamin E on plasma lipoprotein cholesterol levels in male rats. Ann Nutr Metab 30: 94-103, 1986.
122. Street DA et al. Serum antioxidants and myocardial infarction: Are low levels of carotenoids and alpha-tocopherol risk factors for myocardial infarction? Circulation 90; 3:1154-61, 1994.
123. Suzukawa M, Ishikawa T, Yoshida H, Tokorozawa N. Effect of in-vivo supplementation with low-dose vitamin E on susceptibility of low-density lipoprotein and high-density lipoprotein to oxidative modification. J Am Coll Nutr 14:1:46-52, 1995.
124. Suzuki T, Kawase T, Harada T. Clinical study of vitamin E status in patients with chronic liver diseases. Nippon Shokakibyo Gakkai Zasshi 88; 4:1066-73, 1991.
125. Sword J, Pope A, Hoekstra W. Endotoxin and lipid peroxidation in vitro in selenium and vitamin E deficient and adequate rat tissue. J Nutr 121: 251-257, 1991.
126. Sword J, Pope A, Hoekstra W. Endotoxin and lipid peroxidation in vitro in selenium and vitamin E deficient and adequate rat tissue. J Nutr 121: 258-264, 1991.
127. Takamatsu S, Takamatsu M, Satoh K, et al. Effects on health of dietary supplementation with 100 mg d-alpha tocopheryl acetate, daily for 6 years. J Int Med Res 23:342-57, 1995.
128. Tang AM et al. Association between Serum Vitamin A and E levels and HIV-1 disease progression. AIDS 11:613-20, 1997.
129. Taylor A. Associations between nutrition and cataract. Nutr Rev 47: 225-234, 1989.
130. Tolonen M, Markku H, Sarna S. Vitamin E and selenium supplementation in geriatric patients A double-blind preliminary clinical trial. Biol Trace Elem Res 7: 161-168, 1985.
131. Torun M et al. Serum levels of vitamin E in relation to cardiovascular diseases. J Clin Pharm Therap 20:335-40, 1995.
132. Van Den Berg JJ, Roelofsen B, OpdenKamp JAF et al. Vitamin E: Biochemistry and health implications, vol. 570. New York: Ann NY Acad Sci. p 527-529, 1989.
133. Veris Research Summary. The role of antioxidants in prevention of coronary heart disease. p 1-16, Nov. 1996.
134. Verlangieri AJ, Bush MJ. Effects of d-a-tocopherol supplementation on experimentally induced primate atherosclerosis. J Am Coll Nutr 11;2:131-8, 1992.
135. Vitale S et al. Plasma vitamin C, E and beta carotene levels and risk of cataract. Invest Ophthalmol Vis Sci 32:723, 1991.
136. Wald NJ, Boreham J, Hayward JL et al. Plasma retinol beta carotene and vitamin E levels in relation to future risk of breast cancer. Br J Cancer 49: 321-324, 1984.
137. Wang Y, Watson RR. Potential Therapeutics of Vitamin E (Tocopherol) in AIDS and HIV, Drugs 48:327-38, 1994.
138. Weisburger J. Nutritional approach to cancer prevention with emphasis on vitamins, antioxidants and carotenoids. Am J Clin Nutr 53: S226-237, 1991.
139. Welsh AL. Lupus erythematosus: Treatment by combined use of massive amounts of pantothenic acid and vitamin E. Arch Dermatol Syphilol 70: 181-98, 1954.
140. White G. Vitamin E inhibition of platelet prostaglandin biosynthesis. Fed Proc 36: 350, 1977.
141. Yau TM, Weisel RD, Mickle DA, et al. Vitamin E for coronary bypass operations. A prospective, double-blind, randomized trial. J Thorac Cardiovasc Surg 108; 2: 302-10, 1994.
142. Örndahl G et al. Myotonic dystrophy treated with selenium and vitamin E. Acta Med Scand 219: 409-44, 1986.

 

Sources
Joseph E. Pizzorno Jr., Michael T. Murrey & Melvyn R. Werbach.

Vitamin K, Research references

January 1999

1. Avery RA, Duncan WE, Alving BM. Severe vitamin K deficiency induced by occult celiac disease BR96-026. Am J Hematol 53; 1: 55, 1996.
2. Binkley, NC, Suttie, W. Vitamin K nutrition and osteoporosis. J Nutr 125: 1812-1821, 1995.
3. Bottaro G, Fichera A, Ricca O, et al. Effect of the therapy with vitamin K on coagulation factors in
4. celiac disease in children. Pediatr Med Chir 8; 4:551-54, 1986.
5. Ferland, G., Sadowski, JA., O’Brien, ME. Dietary induced subclinical vitamin K deficiency in normal human subjects. J Clin Invest 91: 1761-1768, 1993.
6. Frick PG, Riedler G, Brogli H. Dose response and minimal daily requirement for vitamin K in man. J Appl Physiol 23: 387-389, 1967.
7. Jones DY, Koonsvitsky BP, Ebert ML et al. Vitamin K status of free-living subjects consuming olestra. Am J Clin Nutr 53: 943-946, 1991.
8. Knapen MHJ, Hamuly’ak K, Vermeer C. The effect of vitamin K supplementation on circulating osteocalcin (bone Gla protein) and urinary calcium excretion. Ann Int Med 111: 1001-1005, 1989.
9. Olson RE. The function and metabolism of vitamin K. Ann Rev Nutr 4: 281-327, 1984.
10. Price PA. Role of vitamin K-dependent proteins in bone metabolism. Ann Rev Nutri 8: 565-583, 1988.
11. Sadowski JA, Hood SJ, Dallal GE, Garry PJ. Phylloquinone in plasma from elderly and young adults. factors influencing its concentration. Am J Clin Nutr 50: 100-108, 1989.
12. Suttie, JW. Vitamin K. In: Present knowledge in nutrition. 7th edn. Washington DC: International Life Sciences Press. p 137-45, 1996.

 

Sources
Joseph E. Pizzorno Jr., Michael T. Murrey & Melvyn R. Werbach.

Vitamins in general, Research references

January 1999

1. Ames BN, Berkeley, Univ. CA et al. High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased K-m): relevance to gentic disease and polymorphisms. Am J Clin Nutr, 2002, vol.75, 616-58.
2. Fairfield KM, Fletcher RH, Harvard Medical School, Vitamins for Chronic Disease Prevention in Adults, Scientific Review, JAMA, vol. 287, 3116-26, 2002. (152 refs.)
3. Fletcher RH, Fairffield KM, Vitamins for Chronic Disease Prevention in Adults, Clinical Applications, JAMA, vol. 287, 3127-29, 2002. (23 refs.)

 

Sources
Joseph E. Pizzorno Jr., Michael T. Murrey & Melvyn R. Werbach.

Coenzyme Q10, Research references

January 1999

1. Battino M, Fato R, Lenaz G: Coenzyme Q10 can control the efficiency of oxidative phosphorylation.; Int J Tissue React 12, no. 3, pp. 137-144, 1990.
2. Chen Rou-Shayn et al. Coenzyme Q10 treatment in mitochondrial encephalomyopathies. Eur Neurol 37:212-18, 1997.
3. Folkers K et al. Biochemical rationale and the cardiac response of patients with muscle disease to therapy with coenzyme Q10. Proc Natl Acad Sci U S A 82;13:4513-16, 1985.
4. Folkers K, Wolaniuk J, Sinonsen R, et al, in K. Folkers, Y Yamamura, Eds. Biochemical and Clinical Aspects of Coenzyme Q10, Vol. 5. Amsterdam, Elsevier Science Pub. 353-8, 1985
5. Folkers K, Vadhanavikit S, Mortensen SA. Biochemical rationale and myocardial tissue data on the effective therapy of cardiomyopathy with coenzyme Q10. Proc Natl Acad Sci U S A 1985;82:901-4
6. Folkers K, Langsjoen P, Nara Y, et al. Biochemical deficiencies of coenzyme Q10 in HIV-infection and exploratory treatment. Biochem Biophys Res Commun 153:888-96, 1988.
7. Folkers K, Hanioka T, Xia LJ, et al. Coenzyme Q10 increases T4/T8 ratios of lymphocytes in ordinary subjects and relevance to patients having the AIDS-related complex. Biochem Biophys Res Commun 176; (2):786-91, 1991.
8. Folkers K, Morita M, McRee Jr. J. The activities of coenzyme Q10 and vitamin B6 for immune response. Biochem Biophys Res Commun 193: 88-92, 1993.
9. Fryburg DA et al. The immunostimulatory effects and safety of beta-carotene in patients with AIDS. VIIIth Int Conf on AIDS, Amsterdam, 1992.
10. Sato K. Pharmacoklinetics of coenzyme Q10 in recovery of acute sensorineural hearing loss due to hypoxia. Acta Otolaryngol Suppl (Stockh.) 458: 95-102, 1988.
11. Simonsen R, Folkers K, Komorowski J, et al, in K Folkers, GP Littarru, T Yamagami, Eds. Biochemical and Clinical Aspects of Coenzyme Q10, Volume 6. Amsterdam, Elsevier Science Publ., 363-73, 1991.
12. Sobreira C et al. Mitochondrial encephalomyopathy with coenzyme Q10 deficiency. Neurology 48:1238-43, 1997.
13. Yamabe H, Fukuzaki H, in K Folkers, GP Littarru, Y Yamagami, Eds. Biochemical and Clinical Aspects of Coenzyme Q10, Vol. 6. Amsterdam, Elsevier Sci Pub., 1991: 541-5, 1991.
14. Zeppilli P, Merlino B, DeLuca A, et al, in K Folkers, GP Littarru, Y Yamagami, Eds. Biochemical and Clinical Aspects of Coenzyme Q10, Volume 6. Amsterdam, Elsevier Science Pub. 541-5, 1991.
15. Judy, W.V., Folkers, K.A., & Stogsdill, W.W. (1993). Myocardial preservation by therapy with Coenzyme Q10 during heart surgery. Clinical Investigator; 71(8 Suppl): S155-61.
16. Morisco, C., Trimarco, B., & Condorelli, M. (1993). Effect of Coenzyme Q10 therapy in patients with congestive heart failure: a long-term multicenter randomized study. The Clinical Investigator, 71(8 Suppl), S134-S136.

 

Kilder
Joseph E. Pizzorno Jr., Michael T. Murrey & Melvyn R. Werbach, and others

 

Minerals in general, Research references

January 1999

1. Green TJ, Whiting SJ. Potassium bicarbonate reduces high protein-induced hypercalciuria in adult men. Nutr Res 14:991-1002, 1994.
2. Heyburn PJ et al. Phosphate treatment of recurrent calcium stone disease. Nephron 32, 4:314-19, 1982.
3. Khanniazi MK, Khanam A, Japper Naqvi SA, Sheikh MA. Study of potassium citrate treatment of crystalluric nephrolithiasis. Biomed Pharmacother 47:25-8, 1993.
4. Moss M. Effects of molybdenum on pain and general health: A pilot study. J Nutr Environ Med 5: 55-61, 1995.
5. Munthe E, Aaseth J, Jellum E. Trace elements and rheumatoid arthritis (RA) – pathogenetic and therapeutic aspects. Acta Pharmacol Toxicol (Copenh) 7: 365-73, 1986.
6. Newnham RE. Trace element in man and animals -5. Abstracts. Aberdeen, Scotland. 1984: p 26.
7. Niedermeier W, Griggs JH. Trace metal composition of synovial fluid and blood serum of patients with rheumatoid arthritis. J Chronic Dis 23: 527-36, 1971.
8. Norbiato G et al. Effects of Potassium Supplementation on Insulin Binding and Insulin Action in Human Obesity: Protein-Modified Fast and Refeeding. Europ J Clin Invest 44: 414-19, 1984.
9. Pak CYC et al. Long term treatment of calcium nephrolithiasis with potassium citrate. J Urol 134, 1:11-19, 1985.
10. Pak CY, Fuller C. Idiopathic hypocitraturic calcium-oxalate nephrolithiasis successfully treated with potassium citrate. Ann Intern Med 104, 1:33-7, 1986.
11. Pak CY, Peterson R. Successful treatment of hyperuricosuric calcium oxalate nephrolithiasis with potassium citrate. Arch Intern Med 146, 5:863-7, 1986.
12. Palmqvist E, Tiselius HG. Phosphate treatment of patients with renal calcium stone disease. Urol Int 43; 1:24-8, 1988.
13. Preminger GM et al. Prevention of recurrent calcium stone formation with potassium citrate therapy in patients with renal tubular acidosis. J Urol 134; 1:20-3, 1985.
14. Preminger GM et al. Alkali action on the urinary crystallization of calcium salts: Contrasting responses to sodium citrate and potassium citrate. J Urol 139; 2:240-2, 1988.
15. Rajagopalan KV. Molybdenum: An essential trace element in human nutrition. Ann Rev Nutr 8: 401-27, 1988.
16. Saltman, P.D. & Strause, L.G.: The Role of Trace Minerals in Osteoporosis; Journal of the American College of Nutrition 12, ss. 384, 1993.
17. Schauss A. Minerals, trace elements and human health. 3rd edn. Tacoma, WA: AIBR Life Sciences. 1997.
18. Sandstead HH. Trace element interactions. J Lab Clin Med 98: 457-462, 1981.
19. Vijaya I et al. Trace metal analysis in the aorta with and without atherosclerotic lesions. Trace Elem Electrolytes 12;4:200-2, 1995.

 

Sources
Joseph E. Pizzorno Jr., Michael T. Murrey & Melvyn R. Werbach.

Calcium, Research references

January 1999

1. Adams P, Davies GT, Sweetnam P. Osteoporosis and the effects of aging on bone mass in elderly men and women. J Med New Series 39: 601-615, 1970.
2. Angus RM, Sambrook PN, Pocock NA, Eisman JA. Dietary intake and bone mineral density. Bone Miner 4: 265-277, 1988.
3. Arnaud, DC, Sanchez, SD. Calcium and phosphorous. Present knowledge in nutrition. 6th edn. Washington DC: Nutrition Foundation. p 212-221, 371-373, 1990.
4. Arnaud CD, Sanchez SD. The role of calcium in osteoporosis. Ann Rev Nutr 10: 397-414, 1990.
5. Bhat KS. Plasma calcium and trace minerals in human subjects with mature cataract. Nutr Rep Int 37:157-63, 1988.
6. Calcium pantothenate in arthritic conditions. A report from the General Practitioner Research Group. Practitioner 224: 208-11, 1980.
7. Chu lY, Margen S, Costa FM. Studies in calcium metabolism. Am J Clin Nutr 28: 1028-1035, 1975.
8. Cook J, Dassenko S, Whittaker P. Calcium supplementation. Effect on iron absorption. Am J Clin Nutr 53: 106-111, 1991.
9. Dawson-Hughes B, Jacques P, Shipp C. Dietary calcium intake and bone loss from the spine in healthy postmenopausal women. Am J Clin Nutr 46: 685-687, 1987.
10. Desai S, Baran D, Grimes J et al. Relationship of diet, axial, and appendicular bone mass in normal premenopausal women. Am J Med Sci 293: 218-220, 1987.
11. Elders PJ, Netelenbos JC, Lips P et al. Perimenopausal bone mass and risk factors. Bone Miner 7: 289-299, 1989.
12. Ettinger, B. Role of Calcium in Preserving the Skeletal Health of Aging Women; Southern Medical Journal,  85; (8); 2S22-30, Aug. 1992.
13. Fletcher MP et al. Nutrition and immunology. New York: Alan R. Liss. p 215-239, 1988.
14. Freudenheim JL, Johnson NE, Smith EL. Relationships between usual nutrient intake and bone-mineral content of women 35-65 years of age. Longitudinal and cross-sectional analysis. Am J Clin Nutr 44: 863-876, 1986.
15. Garn SM, Rohmann CG, Wagner B. Continuing bone growth through life. A general phenomenon. Fed Proc 26: 1729-1736, 1967.
16. Goldman L. Treatment of subacute and chronic discoid lupus erythematosus with intensive calcium pantothenate therapy. J Invest Dermatol 11: 95, 1948.
17. Hallberg L, Brune M, Erlandsson M et al. Calcium. Effect of different amounts on nonheme- and heme-iron absorption in humans. Am J Clin Nutr 53: 112-119, 1991.
18. Heaney RP, Recker RR, Saville PD. Calcium balance and calcium requirements in middle-aged women. J Lab Clin Med 92: 964-70, 953-963, 1978.
19. Jowsey J. Osteoporosis. dealing with a crippling bone disease of the elderly. Geriatrics 32: 41-50, 1977.
20. Kanis JA, Passmore R. Calcium supplementation of the diet – I. Br Med J 298: 137-140, 1989.
21. Kanis JA, Passmore R. Calcium supplementation of the diet II. Br Med J 298: 205-208, 1989.
22. Kanders B, Dempster DW, Lindsay R. Interaction of calcium nutrition and physical activity on bone mass in young women. J Bone Miner Res 1988; 3: 145-149.
23. Laval-Jeanet AM, Paul G, Bergot C et al. Correlation between vertebral bone density measurement and nutritional status. In: Proceedings – osteoporosis. Glostrup: Glostrup Hospital. p 953-963, 1984.
24. Linkswiler HM, Joyce CL, Anand CR. Calcium retention of young adult males as affected by level of protein & of calcium intake. Trans NY Acad Sci 36: 333-340, 1974.
25. Mazess RB, Barden HS. Bone density in premenopausal women: Effects of age, dietary intake, physical activity, smoking, and birth-control pills. Am J Clin Nutr 53: 132-142, 1991.
26. New england – Heany, R.P.: Thinking straight about Calcium; New England Journal of Medicine; 328, ss. 503, 1993.
27. Nilas L, Christiansen C, Rodbro P. Calcium supplementation and postmenopausal bone loss. Br Med J 1984; 289: 1103-1106, 1984.
28. Nordin BE, Polley KJ. Metabolic consequences of the menopause. A cross-sectional, longitudinal, and intervention study on 557 normal postmenopausal women. Calcif Tissue Int 41: 1-59, 1987.
29. Penland JG and Johnson PE, Dietary Calcium and Manganese Effects on Menstrual  Cycle Symptoms, Am J Obstet Gynecol 168; 1417-23, 1993.
30. Riggs BL, Wahner HW, Melton LJ 3rd et al. Dietary calcium intake and rates of bone loss in  women. J Clin Invest 80: 979-982, 1987.
31. Riis B, Thomsen K, Christiansen C. Does calcium supplementation prevent post menopausal bone loss? A double-blind, controlled clinical study. New Eng J Med 316: 173-177, 1987.
32. Sowers MR, Wallace RB, Lemke JH. Correlates of forearm bone mass among women during maximal bone mineralization. Prev Med 14: 585-596, 1985.
33. Sowers MR, Wallace RB, Lemke JH. Correlates of mid-radius bone density among postmenopausal women. A community study. Am J Clin Nutr 41: 1045-1053, 1985.
34. Spencer H, Karmer L et al. Effect of a high protein (meat) intake on calcium metabolism in man. Am J Clin Nutr 31: 2167-2180, 1978.
35. Stevenson JC, Whitehead MI, Padwick M et al. Dietary intake of calcium and postmenopausal bone loss. Br Med J 297: 15-17, 1988.
36. Tylavsky FA, Anderson JJ. Dietary factors in bone health of elderly lactoovovegetarian and omnivorous women. B. Am J Clin Nutr 1988; 48: 842-849, 1988.
37. Van Beresteijn EC, van’t Hof MA, de Waard H. Relation of axial bone mass to habitual calcium intake and to cortical bone loss in healthy early postmenopausal women. Bone 11: 7-13, 1990.
38. Webb RC, Bohr DF. Mechanism of membrane stabilization by calcium in vascular smooth muscle. Am J Physiol 235: C227, 1978.
39. Calcium, vitamin D, milk consumption, and hip fractures: a prospective study among postmenopausal women. Diane Feskanich, Walter C Willett, and Graham A Colditz. Am J Clin Nutr 2003;77 504-511 http://www.ajcn.org/cgi/content/abstract/77/2/504

 

Sources
Joseph E. Pizzorno Jr., Michael T. Murrey & Melvyn R. Werbach.

Iron, Research references

  1. Allen, LH. Pregnancy and iron deficiency. Unresolved issues. Nutr Rev 1997; 55: 91-100.
  2. Anonymous. Vitamin A deficiency and anemia. Nutr Rev 1979; 37: 38-40.
  3. Anonymous. Vitamin A deficiency and iron nutriture. Nutr Rev 1984; 42: 167-168.
  4. Ballin A, Berar M, Rubinstein U, et al. Iron state in female adolescents. Am J Dis Child 146(7): 803-5, 1992.
  5. Ballott DE, MacPhail AP, Bothwell TH et al. Fortification of curry powder with NaFe(111) EDTA in an iron-deficient population. Initial survey of iron status. Am J Clin Nutr 1989; 49: 156-161.
  6. Bates CJ et al. Vitamins, iron, and physical work. Lancet ii: 313-14, 1989.
  7. Beard, JL, Dawson H, Pinero, DJ. Iron metabolism. A comprehensive review. Nutr Rev 1996; 54: 295-317.
  8. Beutler E, Larsh SE, Gurney CW. Iron therapy in chronically fatigued, nonanemic women; a double-blind study. Ann Intern Med 1960; 52: 378-394.
  9. Blake DR et al. The importance of iron in rheumatoid disease. Lancet ii: 1142-4, 1981.
  10. Blake DR et al. Effect of intravenous iron dextran on rheumatoid synovitis. Ann Rheum Dis 44: 183-8, 1985.
  11. Buetler E, Larsh SE, Gurney CW. Iron therapy in chronically fatigued non-anemic women: A double blind study. Ann Intern Med 52: 378-94, 1960.
  12. Chua ACG, Morgan EH. Effects of iron deficiency and iron overload on manganese uptake and deposition in the brain and other organs of the rat. Biol Trace Elem Res 1996; 55: 39-54.
  13. Cook J, Dassenko S, Whittaker P. Calcium supplementation. Effect on iron absorption. Am J Clin Nutr 1991; 53: 106-111.
  14. Dallman PR, Beutler E, Finch CA. Effects of Iron deficiency exclusive of anaemia Br J Haematol 1978; 40: 179-184.
  15. Dallman, PR. Iron. In: Present knowledge in nutrition. 6th edn. Washington DC: Nutrition Foundation. 1990: p 241-250.
  16. Dalton MA et al. Calcium and phosphorous supplementation of iron-fortified infant formula. No effect on iron status of healthy full-term infants. Am J Clin Nutr 1997; 65: 921-926.
  17. Edgerton VR, Ohira Y et al. Toleration of hemoglobin and work tolerance in iron deficient subjects. J Nutr Sci Vitaminol 1981; 27: 77-86.
  18. Fairweather Tait SJ, Minihane AM, Eagles J et al. Rare earth elements as nonabsorable fecal markers in studies of iron absorption. Am J Clin Nutr 1997; 65: 970-976.
  19. Dabbagh AJ. Trenam CW, Morris CJ, Blake DR. Iron in joint inflammation. Ann Rheum Dis 52:67-73, 1993.
  20. Dabbagh AJ. Trenam CW, Morris CJ, Blake DR. Iron in joint inflammation. Ann Rheum Dis 52:67-73, 1993.
  21. Davidson A et al. Red cell ferritin content: A re-evaluation of indices for iron deficiency in the anaemia of rheumatoid arthritis. Br Med J 289: 648-50, 1984.
  22. Gardner GW et al. Physical work capacity and metabolic stress in subjects with iron deficiency anemia. Am J Clin Nutr 30; 6: 910-17, 1977.
  23. Gleerup A, Rossander-Hulthen L, Gramatkovski E et al. Iron absorption from the whole diet: comparison of the effect of two different distributions of daily calcium intake. Am J Clin Nutr 1995; 61: 97-104.
  24. Green R, Charlton R et al. Body iron excretion in man; a collaborative study. Am J Med 1968; 45: 336-353.
  25. Hallber L. Bioavailability of dietary iron in man. Ann Rev Nutr 1981; 1: 123-147.
  26. Hallberg L, Nilsson L. Constancy of individual menstrual blood loss. Acta Obstet Gynecol Scand 1964; 43: 352-359.
  27. Hallberg L, Rossander L, Persson H. Deleterious effects of prolonged warming of meals on ascorbic acid content and iron absorption. Am J Clin Nutr 1982; 36: 846-850.
  28. Hallberg L, Brune M, Erlandsson M et al. Calcium. Effect of different amounts on nonheme- and heme-iron absorption in humans. Am J Clin Nutr 1991; 53: 112-119.
  29. Hansen TM et al. Serum ferritin and the assessment of iron deficiency in rheumatoid arthritis. Scand J Rheumatol 12; 4: 353-9, 1983.
  30. Hansen TM, Hansen NE. Serum ferritin as indicator of iron responsive anemia in patients with rheumatoid arthritis. Ann Rheum Dis 45: 569, 1986.
  31. Hunt, JR, Gallagher, SK, Johnson, LK. Effect of ascorbic acid on apparent iron absorption by women with low iron stores. Am J Clin Nutr 1994; 59: 1381-1385.
  32. Kent S, Weinberg E. Hypoferremia. Adaptation to disease? New Eng J Med 1989; 320: 672.
  33. Kies C, ed. Nutritional bioavailability of iron. Washington, DC: American Chemical Society. 1982.
  34. Kies, C, Bylund, DM. Iron status of adolescent boys and girls as influenced by variations in dietary ascorbic acid and iron intakes. Nutr Rep Intl 1989; 40: 43-51.
  35. Li R, Chen X, Yan H, et al. Functional consequences of Iron Supplementation in iron-deficient female cotton mill workers in Beijing, China. Am J Clin Nutr 59: 908-13, 1994.
  36. Lynch, SR. Interaction of iron with other nutrients. Nutr Rev 1997; 55: 102-110.
  37. Magnusson B, Bjorn-Rasmussen E, Hallberg L et al. Iron absorption in relation to iron status. Model proposed to express results of food iron absorption measurements. Scand J Haematol 1981; 27: 201-208.
  38. McCord, JM. Effects of positive iron status at a cellular level. Nutr Rev 1996; 54: 85-88.
  39. Muirden KD, Senator GB. Iron in the synovial membrane in rheumatoid arthritis and other joint diseases. Ann Rheum Dis 27: 38-48, 1968.
  40. Ohira Y, Edgerton VR, Gardner GW et al. Work capacity after iron treatment as a function of hemoglobin and iron deficiency. J Nutr Sci Vitaminol 1981; 27: 87-96.
  41. Oski FA, Honig AS, Helu B, Howanitz P. Effect of iron therapy on behavior performance in nonanemic, iron-deficient infants. Pediatrics 1983; 71: 877-880.
  42. Oski FA, Honig AS. The effects of therapy on the developmental scores of iron deficient infants. J Pediatr 1978; 92: 21-25.
  43. Pollitt E, Leibel RL. Iron deficiency and behavior. J Pediatr 1976; 88: 372-381.
  44. Pollitt E, Leibel RL, Greenfield DB. Iron deficiency and cognitive test performance in preschool children. Nutr Behavior 1983; 1: 137-146.
  45. Pollitt E, Soemantri AG, Yunis F, Scrimshaw NS. Cognitive effects of iron-deficiency anaemia. Lancet 1985; 1: 158.
  46. Prasad MK, Pratt CA. The effects of exercise and two levels of dietary iron on iron status. Nutr Res 1990; 10: 1273-1283.
  47. Rothwell RS, Davis P. Relationship between serum ferritin, anemia, and disease activity in acute and chronic rheumatoid arthritis. Rheumatol Int 1; (2): 65-7, 1981.
  48. Scrimshaw NS. Functional consequences of iron deficiency in human populations. J Nutr Sci Vitaminol 1984; 30: 47-63.
  49. Sempos, CT, Looker, AC, Gillum, RF. Iron and heart disease. The epidemiologic data. Nutr Rev 1996; 54: 73-88.
  50. Sheard, NF. Iron deficiency and infant development. Nutr Rev 1994; 52: 137-140.
  51. Stãhlberg MR, Savilahti E, Siimes MA. Iron deficiency in coeliac disease is mild and it is detected and corrected by gluten-free diet. Acta Paediatr Scand 80; (2):190-3, 1991.
  52. Tucker DM, Sandstead HH, Penland JG et al. Iron status and brain function: serum ferritin levels associated with asymmetries of cortical electrophysiology and cognitive performance. Am J Clin Nutr 1984; 39: 105-113.
  53. Voorhees ML, Stuart MJ et al. Iron deficiency anemia and increased urinary norepinephrine. J Pediatr 1g74; 86: 542-547.
  54. Vreugdenhil G et al. Efficacy and safety of oral iron chelator L1 in anaemic rheumatoid arthritis patients. Letter. Lancet ii: 1398-9, 1989.
  55. Walter T, Olivares M, Pizarro F et al. Iron, anemia, and infection. Nutr Rev 1997; 55: 111-124.
  56. Webb TE, Oski FA. Iron deficiency anemia and scholastic achievement in young adolescents. J Pediatr 1973; 82: 827-830.
  57. Webb TE, Oski FA. Behavioral status of young adolescents with iron deficiency anemia. J Spec Educ 1974; 8: 153-156.
  58. Willis WT et al. Iron deficiency: Improved exercise performance within 15 hours of iron treatment in rats. J Nutr 120; 8: 909-16, 1990.
  59. Yip, R, Dallman, PR. Iron. In: Present knowledge in nutrition. 7th edn. Washington, DC: Nutrition Foundation. 1996: p 277-292.
  60. Zittoun J, Blot 1, Hill C et al. Iron supplements versus placebo in pregnancy. Its effects on iron and folate status on mothers and newborns. Ann Nutr Metabol 1983; 27: 320-327.

Sources:
Joseph E. Pizzorno Jr., Michael T. Murrey & Melvyn R. Werbach.